It's good to make sure that the other players are aware that your character's actions within the game are not a reflection of your real life relationships, and are not motivated by anything but in-character roleplaying.

On the other hand, there's a certain amount of satisfaction to be gained from inviting someone you secretly hate around for a game of Paranoia.

Transcript

Ben: Hi Annie, Pete.
Annie: Hi Ben. And Sally! It's nice to see you again.
Pete: I thought you'd started ice skating lessons.
Sally: Skating is stupid. I'm going to be a fashion designer instead.
Pete: Good idea. Someone needs to drive the arbitrary cycle of frivolous consumerism.
Sally: Yeah!
Obi-Wan: Annie, were you really going to leave Obi-Wan to die on Dookû's ship?
Anakin: It's in character for Anakin. Is that okay?
Obi-Wan: Yes, that's fine. If Obi-Wan finds out, though, it's logical for him to follow the... natural course of events.
Anakin: Totally. You have to be true to your character.
Obi-Wan: So we're good on this?
Anakin: Of course, Ben. This is fun.
Obi-Wan: I concur.
{beat}
R2-D2: What just happened?
Sally: Nothing. Skating's just dumb, okay?